BIOGRAPHICAL SKETCH
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Biomedical Engineering Department, Engineering Faculty,
the University of Isfahan, HezarJerib.st. E-mail: m.mehdikhani@eng.ui.ac.ir Homepage: http://eng.ui.ac.ir/~m.mehdikhani/ |
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NAME: Mehdikhani, Mehdi
POSITION TITLE: Associate Professor of Biomedical Engineering
EDUCATION/TRAINING
INSTITUTION AND LOCATION |
DEGREE (if applicable)
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Start Date MM/YYYY |
Completion Date MM/YYYY
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FIELD OF STUDY
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Isfahan University of Technology, Isfahan, IRAN |
Ph.D. |
09/2005 |
02/2011 |
Biomaterials |
Isfahan University of Technology, Isfahan, IRAN |
M.Sc. |
09/2001 |
02/2004 |
Materials Engineering-Corrosion and Protection of Materials |
Islamic Azad University, Najafabad , Isfahan, IRAN |
B.S |
09/1996 |
09/2000 |
Materials Engineering |
A. Research Interest
My research is focused on ‘Biomaterials for regenerative medicine and their use in drug delivery systems. I am interested in developing biodegradable polymer-based composites for bone, cartilage, skin, heart, nerve, ocular, and gastrointestinal tract tissue engineering. Rational design and development of novel biodegradable polymer scaffolds with customized properties tailored to deliver drugs in a time-dependent manner to induce specific tissue regeneration is my considerable interest. Furthermore, I am working on surface modification of the scaffolds to improve cell interaction and enhanced properties in vivo.
B. Positions and Honors
2011-2014 Assistant Professor, Department of Materials Engineering, Faculty of Engineering, Semnan University, Semnan, IRAN
2014-2021 Assistant Professor, Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, IRAN.
2021- Ongoing Associate Professor, Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, IRAN.
Reviewer in the international journals
2014-Present Reviewer in the international journals (Materials Science & Engineering C, Journal of Medical Signals and Sensors, Dental Research Journal, Polymer Testing, Fibers and Polymers, etc.)
2015 Outstanding presentation in the idea festival in improving research at Isfahan University of
Medical Sciences
2012-2017 Iran National Science Foundation
2015-2017 Council for Stem Cell Sciences & Technologies
C. Contributions to Science
Published ISI papers in the research lines
26. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Hashemi-Beni B, Razavi SM, Novel poly (lactide-co-glycolide)/bioactive glass/hydroxyapatite nanocomposite coating for dental applications. Materials Science: Materials in Medicine. 2012; 23: 485-495 (2012).
27. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Razavi SM, Subcutaneous connective tissue reactions to the three types of bioactive glass nanopowders. Journal of Biomedical Nanotechnology. 2011; 7(3): 460-465.
28. Mortazavi V, Mehdikhani-Nahrkhalaji M, Fathi MH, Mousavi SB, Nasr- Esfahani B, Antibacterial effects of sol-gel derived bioactive glass nanoparticle on aerobic bacteria. Journal of Biomedical Materials Research Part A. 2010; 94A: 160-168.
Selected Published ISC and other papers
1. Falak M, Mehdikhani M, Varshosaz J, Hashemibeni, Ebrahimian-Hosseinabadi M, Fabrication and evaluation of spironolactone-loaded nanostructured lipid carries for cardiac tissue regeneration, 10 (4); 2020: 260-265.
2. Haghighat A, Mehdikhani-Nahrkhalaji M, Reihani A, Soltani-Dehnavi Sh, Eblaghian G. Novel Chitosan/Polyethylene Glycol/Bioactive glass Nanocomposite membrane for Guided Tissue/Bone Regeneration. International Journal of Advanced Biotechnology and Research. 2017; 8(2): 787-800.
3. Tavakoli E, Mehdikhani-Nahrkhalaji M, Sarafbidabad M. Poly (Lactic-co-Glycolic) Acid (PLGA)-Based Compounds for Articular Cartilage Regeneration. Journal of Reports in Pharmaceutical Sciences. 2016; 5(2): 94-103.
4. Nazemi Z, Mehdikhani-Nahrkhalaji M, Haghbin Nazarpak M, Staji H. The antibacterial activity evaluation of sol-gel prepared Zn-doped biphasic calcium phosphate nanopowders. Advanced Science, Engineering and Medicine. 2015; 7: 995-1002.
5. Mehdikhani-Nahrkhalaji M, Mohammad Hossein Fathi, Vajihesadat Mortazavi, Sayed Behrouz Mousavi, Ali Akhavan, Abbas Haghighat, Batool Hashemi-Beni, Sayed Mohammad Razavi, Fatemeh Mashadiabbas. Biocompatibility Evaluation of Biodegradable Nanocomposite coatings for dental and orthopaedic implant applications. Dental Research Journal. 2015; 12(1): 89-99.
6. Mehdikhani-Nahrkhalaji M, Mohammad Hossein Fathi,Vajihesadat Mortazavi, Sayed Behrouz Mousavi, Batool Hashemi-Beni, Sayed Mohammad Razavi, Ali Akhavan, Abbas Haghighat. In Vivo and In Vitro Evaluation of Poly (lactide-co-glycolide)/Bioactive Glass Nanocomposite Coating. Advanced Materials Research. 2014; 829: 309-313.
7. Parsapour A, Fathi MH, Salehi M, Saatchi A, Mehdikhani M. The Effect of Surface Treatment on corrosion behavior of Surgical 316L Stainless Steel Implant. International Journal of Iron & Steel Society of Iran. 2007; 4(1,2): 34-38.
8.
Selected Conferences and Proceedings
1. Shahravi Z, Mehdikhani M, Amirkhani Mohammad Amir, Farsaei S, Molapour Sisakht Mahsa. Design of Novel Blend of Gellan Gum / Polyvinyl Alcohol as Nano-fibrous Scaffold for Wound Dressings with Appropriate Mechanical Properties, 4th International and 6th National Congress of Wound and Tissue Repair, 2019 November 19, Iranian Society of Dermatology, Razi Hall, Tehran, Iran.
2. Mehdikhani M. New approaches to the tissue engineering. Symposium of application of Biotechnology in Medical Science, 2018 April 13, Royan Institute, Isfahan, Iran.
3. Torabi H, Mehdikhani M. Injectable hydrogels for myocardial tissue regeneration. The First International Iranian Tissue Engineering and Regenerative Medicine Congress (ITERMC), 2018 July 18-20, Tehran, Iran.
4.
Ghaziof Sh, Mehdikhani M. Renovaton of the injured
myocardial tssue with new conductve, biodegradable, and non-cytotoxic
polymer matrix coated with fbrin glue nanocomposite scaffold. Annual Biotechnology
Congress, 2017 August 17-18, Toronto, Canada.
5. Ghaziof Sh, Mehdikhani-Nahrkhalaji M. New conductive nanocomposite scaffold coated with fibrin glue for myocardial tissue engineering, Global Congress on Tissue Engineering and Regenerative Medicine,2016 December 1-2, San Antonio, USA.
6. Ghaziof S, Mehdikhani-Nahrkhalaji M, Novel polycaprolactone/ Carbon nanotubes nanocomposite scaffold for cardiac tissue engineering, 5th International Conference on Tissue Engineering and Regenerative Medicine, 2016 September 12-14, Berlin, Germany.
7. Mehdikhani-Nahrkhalaji M, Ghaziof S. Preparation, Characterization, Mechanical, and Electrical Conductivity Assessment of Novel Polycaprolactone / Multi Wall Carbon Nanotubes Nanocomposites for Myocardial Tissue Engineering. 6th International Advances in Applied Physics and Materials Science Congress & Exhibition (APMAS2016), 2016 1-3 June, Steigenberger Hotel Maslak, Istanbul,Turkey.
8. Sattari E, Hasanzadeh Nemati N, Mehdikhani-Nahrkhalaji M. Coating of mesoporous bioactive glass nanospheres on stainless steel 316Lby sol-gel method. The First International Conference on Science and Engineering, 2015, 1st of December, Dubai.
9. Aghazadeh S, Hasanzadeh Nemati N, Mehdikhani-Nahrkhalaji M. Feassibility study on application of mesoporous bioactive glass nanospheres as a filler of cancerous bone defects. The First International Conference on Science and Engineering, 2015, 1st December, Dubai.
10. Reihany A, Mehdikhani-Nahrkhalaji M, Haghighat A. Preparation and characterization of chitosan-45S bioactive glass nanocomposite membrane for guided tissue regeneration. 26th European Students ’ Conference, 2015, 23-26 September, Berlin, Germany.
11. Aghazadeh S, Hasanzadeh Nemati N, Mehdikhani-Nahrkhalaji M. The effect of calcium oxide in bioactive glass composition on the preparation of spherical mesoporous nanoparticles for medical applications. The International Conference on New Research in chemistry and Chemical Engineering, 2015, 17 September, Tehran, Iran.
12. Tavakoli E, Mehdikhani-Nahrkhlaji M, Hashemi_beni B, Zargar-Kharazi A. Preparation, Characterization, and mechanical assessment of Poly (Lactic-co-Glycolic) Acid (PLGA) / Hyaluronic acid (Ha)/ Fibrin/ Bioactive glass Nano-composite scaffolds for cartilage tissue engineering applications. the 5th international conference on Ultrafine Grained and Nanostructured Materials, 2015, 11-12 November, Tehran, Iran.
13. Khandan A, Karamian E, Mehdikhani-Nahrkhalaji M, Mirmohammadi H, Farzadi A, Ozada N, Heidarshenas B, Zamani K. Influence of Spark Plasma Sintering and Baghdadite Powder on Mechanical Properties of Hydroxyapatite. 5th international conference on Ultrafine Grained and Nanostructured Materials, 2015, 11-12 November, Tehran, Iran.
14. Raziye I, Mehdikhani-Nahrkhalaji M, Karbasi S. Nanocomposites scaffold fabricated by electrospinning for bone tissue engineering. International Congress on Nanoscience & Nanotechnology 2014, 22-24 October, Tarbiat Modares University, Tehran,Iran.
15. Nazemi Z, Mehdikhani-Nahrkhalaji M, Haghbin-Nazarpak M. Synthesis and characterization of Zn doped biphasic calcium phosphate nanoparticles prepared by sol-gel method. International Congress on Nanoscience & Nanotechnology, 2014, 22-24 October, Tarbiat Modares University, Tehran,Iran.
16. Soltani-Dehnavi Sh, Mehdikhani-Nahrkhalaji M, Rafienia M, Doostmohammadi A. Antibacterial activity of sol-gel derived copper-incorporated and copper free bioactive glass nanoparticles on a gram-positive bacterium. 5th International Congress on Nanoscience & Nanotechnology, 2014, 22-24 October, Tarbiat Modares University, Tehran, Iran.
17. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V. In vivo and In Vitro evaluation of poly (lactide-co-glycolide)/bioactive glass nanocomposite coating in rabbit tibiae. 4th international conference on Ultrafine Grained and Nanostructured Materials, 2013, Tehran University, Tehran, Iran.
18. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Hashemi-Beni B. Poly (DL-lactide-co-glycolide)/ Bioactive glass nanocomposite coating for orthopedic and dental applications. Proceedings of the 4th International Conference on Nanostructures, 2012, 12-14 March, Kish Island, I.R. Iran.
19. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Hashemi-Beni B. Poly (DL-lactide-co-glycolide)/ Bioactive Glass/Hydroxyapatite nanocomposite coating for dental implant applications. The 6nd Annual Meeting of the IADR Iranian Division, Session Title: Oral and Maxillofacial Surgery and Implantology, 2011, 29-30 December, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
20. Mehdikhani Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Hashemi Beni B. Characterization and cytotoxicity evaluation of poly (DL-lactide-co- glycolide)/bioactive glass/hydroxyapatite nanocomposite coating on titanium, using human adipose derived mesenchymal stem cell. Proceedings of the 3rd Conference on Nanostructures, 2010, March 10-12, Kish Island, Iran.
21. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Razavi SM. Subcutaneous connective tissue reactions to the three types of bioactive glass nanopowders. Diffusion in Solids and Liquids Conference, 2010, 5-7 July, Paris, France.
22. Mortazavi V, Fathi MH, Mehdikhani Nahrkhalaji M. Antibacterial effects of bioactive glass nanopowders with different compositions. European Society for Artificial organs (ESAO), 2009, 2-5 September, Université de Technologie de Compiègne, , France, Sept 2-5, 2009.
23. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB. Preparation, characterization and bioactivity evaluation of bioactive glass nano-powders with three different compositions. New Materials National Congress, Materials and Energy Research Center, 2008, 10-12 June, Tehran, Iran.
Winning National Projects:
1. Mehdi Mehdikhani (PI), Mohammad Rafienia, Shahin Bonakdar, Shiva Soltani-Dehnavi, Ali Doostmohammadi, Preparation and characterization of Polycaprolactone/Copper Doped Bioactive Glass Nanoparticles, The Office of President, Vice-Presidency for Science and Technology, Iran National Science Foundation, Start Date 06Apr2014 and End Date 16Dec2017.
2. Mehdi Mehdikhani (PI), Anousheh Zargar Kharazi, Ebrahim Tavakoli, Fabrication, Characterization, and Evaluation of Bioactivity and Mechanical Properties of PLGA/FG/HA/nBG Nanocomposite Scaffold for Cartilage Tissue Engineering Application and Investigating the Attachment and Viability of Adipose Derived Mesenchymal Stem Cells on It, Start Date 04Apr2015 and End Date 19Dec2017.
Books:
Pharmaceutics: Drug Delivery and Targeting, Perrie, Yvonne; Rades, Thomas, Second edition, Pharmaceutical Press, 2012, Translated by Mehdi Mehdikhani, Ebrahim Tavakoli, Bahjat Nafari, University of Isfahan Press.
Graduate Students:
1. Shadi Emadi, PhD student of Biomedical Engineering, Thesis Title: Fabrication, characterization, and evaluation of the properties of a 3D printed bilayer polycaprolactone/polyvinyl alcohol with a porous hollow tubular structure coated with an electrospun core-shell polycaprolactone/alginate/sildenafil citrate/vascular endothelial growth factor layer wound dressing. Supervisor: Mehdi Mehdikhani.
2. Mehdi Nabizadeh, PhD student of Biomedical Engineering, Thesis Title: Investigating the effect of optogenic technology on bone tissue restoration in polycaprolactone-alginate-carbon quantum dot nanocomposite scaffold with in vitro and in vivo tests. Supervisor: Mehdi Mehdikhani.
3. Mahtab Motamedi, MSc student of Biomedical Engineering, Thesis Title: Design and evaluation of mitomycin and chrysin drug delivery system based on pH responsive nanoliposomes for breast cancer treatment. Supervisor: Mehdi Mehdikhani.
4. Samineh Ghazvini, MSc student of Biomedical Engineering, Thesis Title: Characterization and evaluation of anticancer properties of liposomes containing doxorubicin and chrysin on breast cancer cells. Supervidor: Mehdi Mehdikhani
5. Parinaz Hosseini, MSc student of Biomedical Engineering, Thesis Title: Fabrication and evaluation of physico-chemical properties of bilayer nanofiber membrane Polycaprolactone-Propolis and Polycaprolactone / Polyvinylalcohol -deferoxamine prepared by 3D printing and electrospinning for use in wound healing. Supervisor: Mehdi Mehdikhani.
6. Zahra Ahmadiyan, MSc student of Biomedical Engineering, Thesis Title: Characterization of properties of injectable hydrogel based on pluronic acid and gold nanoparticles containing omega-3 drug encapsulated in polyglycerol sebasate in order to regenerate myocardial muscle.
The complete conference presentation list (http://eng.ui.ac.ir/~m.mehdikhani)
D.
Additional Information: Courses
YEAR |
COURSE TITLE |
MAJOR |
2011- |
Biocompatibility |
BME, M.Sc. |
2012- |
Physiology |
BME, B.S, M.Sc. |
2012-
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Anatomy |
BME, B.S, M.Sc. |
2011-2014 |
Tissue engineering |
BME, M.Sc. |
2011- |
Biological experiments and sterilization methods
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BME, M.Sc. |
2012- |
Novel systems for delivery of biologic materials |
BME, M.Sc. |
2013- |
Polymers and their applications in biomedical engineering
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BME, M.Sc. |
2011- |
Ceramics and their applications in biomedical engineering
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BME, M.Sc. |
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2016- |
Specialized English Language |
BME, M.Sc. |
BME: Biomedical Engineering
E. Additional Information: Distinguished Researcher
Item |
Value |
Web address |
ORCID |
0000-0002-6809-2891 |
https://orcid.org/0000-0002-6809-2891 |
Researcher ID |
B-1421-2018 |
http://www.researcherid.com/rid/B-1421-2018 |
Scopus Author ID |
36080960500 |
https://www.scopus.com/authid/detail.uri?authorId=36080960500 |
Google Scholar |
Mehdi Mehdikhani |
https://scholar.google.com/citations?user=KsaJoCUAAAAJ&hl=en |
Researchgate |
Mehdi Mehdikhani |
https://www.researchgate.net/profile/Mehdi_Mehdikhani |